I can't really see the two of them having kids, and while part of that is because I imagine they're a bit busy Defending the Earth and possibly travelling in their baby TARDIS, the other part is this, that I can't see the Doctor wanting that. I know having kids with Rose is different than having some genetic sample stolen at gunpoint and turned into a fully-grown gun-toting daughter, but the general sentiment -- that he's had kids (and grandkids and great-grandkids) before and lost them and doesn't want to do that again -- is still there. Plus while the real Doctor may learn some day that Jenny didn't actually die, this one never will, and I can't really see him being able to get over that.

Buuuut that's just my opinion, obviously.

Thanks!